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ORIGINAL ARTICLE
Year : 2019  |  Volume : 5  |  Issue : 1  |  Page : 31-34

To Evaluate the Levels of PT, APTT & Fibrinogen Values in Patients With Type 2 Diabetes Mellitus


1 Senior Resident, Dept of Biochemistry, NMCH, Patna, India
2 Professor & HOD, Dept of Biochemistry, NMCH, Patna, India
3 Assistant Professor, Dept of Pediatrics, NMCH, Patna, India

Correspondence Address:
Rakesh Kumar
Assistant Professor, Department of Pediatrics, Nalanda Medical College & Hospital, Patna-7
India
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Source of Support: None, Conflict of Interest: None


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Introduction: Complication of diabetes mellitus (DM) includes coagulation impairment. Hypercoagulable state in patient with DM may accelerate thromboembolic risk for cardiovascular diseases (CVD). Hyperglycemia in diabetes contributes to hyperfibrinogenemia and activates the coagulation cascade thereby producing atherothrombotic events. Objective: This study was designed to evaluate the coagulation profile (Activated partial thromboplastin time, Prothrombin time and Fibrinogen) in Type 2 diabetes Mellitus. Methods: This study included 100 type 2 diabetics and 50 controls. Fasting blood glucose, coagulation parameters such as prothrombin time, activated partial thromboplastin time and fibrinogen along with other biochemical parameters were investigated. Results: In this study fibrinogen was found to be significantly higher (p-value = 0.000) in diabetic patients as compared to the control group. Prothrombin time in Diabetes Mellitus type 2 is shortened as compared to Non- Diabetic Population whereas APTT is slightly prolonged in DM Type 2. Conclusion: From this study, it may be concluded that diabetic patients are prone to develop coagulation impairment.


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