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ORIGINAL ARTICLE
Year : 2019  |  Volume : 5  |  Issue : 1  |  Page : 72-77

Comparative Study of Procalcitonin and C-Reactive Protein Concentrations as Early Marker of Neonatal Sepsis : A Hospital Based Study


1 Junior Resident, Department of Pediatrics, Kurji Holy Family Hospital, Patna, India
2 Assistant Professor, Department of Pediatrics, IGIMS, Patna, India
3 Consutant, Department of Pediatrics, Kurji Holy Family Hospital, Patna, India
4 Associate Professor, Department of Pediatrics, IGIMS, Patna, India
5 Professor & HOD, Department of Pediatrics, IGIMS, Patna, India

Correspondence Address:
Sunil Kishore
Assistant Professor Department of Pediatrics, IGIMS, Patna
India
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Source of Support: None, Conflict of Interest: None


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Background: Neonatal sepsis is one of the important causes of neonatal morbidity and mortality particularly in the developing countries. In order to avoid unnecessary NICU admissions and antibiotic therapies, it is very important to make early diagnosis of neonatal sepsis with utmost accuracy. Blood culture though gold standard requires lot of time for diagnosis, hence it's necessary to rely on early diagnostic markers such as blood counts, micro-erythrocyte sedimentation rate(ESR), C reactive protein (CRP), Procalcitonin(PCT). Out of the early diagnostic markers available, CRP and pro-calcitonin has the highest sensitivity and specificity rates. Methods: The present study was a hospital based prospective observational study Conducted for a period of one year from 1year (May 2016- April 2017) On neonates admitted to NICU, at Kurji Holy Family Hospital, Patna Bihar which is a tertiary care referral hospital for children. Proper consent was taken from the parents of all neonates. Specimen of blood obtained from each neonate with proper aseptic conditions and prior to commencement of antibiotics. Results: Total of 155 neonates satisfying the inclusion criteria were taken in the study group, based on the above criteria, they were grouped into 3 categories, 93/150 neonates had clinical/no sepsis, 45/155 had probable sepsis and definite sepsis was found in 17/155 neonates. Appropriate investigations were done. Blood culture was positive in 17 neonates. Procalcitonin was negative in 96 neonates, positive (>0.5ng/ml) in 59 neonates, PCT is positive in 12/17 blood culture positive cases. CRP was positive in 43/155 cases, and negative in 112/155 cases. CRP was positive in 11/17 blood culture positive cases. Procalcitonin in comparison with CRP, sensitivity was100%, specificity was 85.72%, positive predictive value (PPV) was 72.88%, and negative predictive value (NPV) was 100%. CRP in comparison with Procalcitonin, sensitivity was 72.88%, specificity was 100%, PPV was 100%, and NPV was 85.72%. Conclusions: Procalcitonin in comparison with CRP shows better sensitivity and negative predictive value.


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